Memory Enhancing Property of Santalum album L. on Mice

 

 

S Papaiah*­­, V Ranjith Babu­­, T Sivanageswara Rao, DD Jackson, KL Senthilkumar

Padmavathi College of Pharmacy and Research Institute, Dharmapuri, Tamilnadu.

 

ABSTRACT:

A lot of medicinal plants, traditionally used for thousands of years, are present in a group of herbal preparations of the Indian traditional health care system (Ayurveda) named Rasayana proposed for their interesting anti-oxidant activities. But the recent study suggests that herbal drugs have a complex pathology to cure Alzheimer’s disease. Alzheimer’s disease is an age related neuro degenerative condition associated with cognitive. Among the different plants, one of them has been specially investigated that they have the Anti-oxidant property. A number of plants constitute the Anti-oxidant activity,  in which one of them is “Santalum album L.” . It was described in one of the siddha system that S. album possesses the property of increasing the memory and cognitive. And also in the Ayurvedic formulation Smruthi leha also described that S.album having the property to decrease dementia in older people. Male albino mice of weighing around 15-20 gm which are one month old were taken for study. The mice were divide into seven groups, in each group a minimum of six animals are taken. They are induce with β-amyloid protein for memory loss. These memory lossed animals are treated with the alcoholic extract of Santalum album L. for a period of 30 days. Then the enzyme estimation is performed on these mice. The results shows that the Santalum album has the property of increased enzyme levels. That it gives the conclusion that Santalum album L.  is having the memory enhancing property.

 

KEY WORDS:

 

INTRODUCTION:

Planet earth has more than 50 million species of plants, animals and microorganisms and hardly 2 million of them have been described by man so for.

 

Plants have been used in the treatment of various diseases from time immemorial. Out of 4,80,000 species of plants only 3,22,311 have been identified. There are 20,000 to 25,000 species of flowering plants are growing on earth which belong to 10,500 genera are source of drugs.1

 

Natural products are obtained from plants, animals, or mineral kingdom and, so these are called as drug of biological origin. Most of the crude drugs used in medicine are obtained from plants and only a small number comes from animal and mineral kingdom. Drugs obtained from plants consist of entire plants or their parts. Generally out of the total of about 2,25,000 species of know plants, about 33,000 are claimed to have medicinal properties.2

 

Brief account on Alzheimer’s disease:

Alzheimer’s disease is a progressive neuro degenerative disorder which effects older individual and is the most common cause of dementia. Atropy of cortical and sub cortical areas is associated with deposition of  β-amyloid protein in the form of senile plaques and formation of neurofibrillary tangles13. There is a marked cholinergic deficiency in the brain and also some of the other transmitter system are also affected.  


As it is a complex neuro degenerative disease with cognitive behavioral and neurological manifestations.

 

It was first discribed in1906 by the German psychiatrist and neuropathologist “Aloi’s Alzheimers”. Alzheimer’s disease is heterogeneous and can be divided into Early Onset Alzheimer’s Disease (EOAD), and Late Onset Alzheimer’s Disease (LOAD)14.

 

Early onset Alzheimer’s disease is caused by autosomal dominant mutation in the APP gene on chromosome 21, the presenilin-1 gene (PS1) on chromosome 14 or the presenilin-2 gene (PS2) on chromosome114.

 

The Late onset Alzheimer’s disease is associated with the presence of Apolipoprotien E (APOE) of the ε.4 allele. The most important risk factor for the development of late on set Alzheimer’s disease (LOAD) is increasing age14.

 

Most common causes of Alzheimer’s disease:

The slowly progressing destruction of nerve cells in the brain causes the AD.

The causes of Alzheimer’s disease;

1.      Amyloid-β peptide deposition(Aβ)

2.      Neuro fibrillary Tangles (NFT’S) and Tau

3.      Cholesterol

4.      Apolipoprotein E4

5.      Oxidative damage of Apoptosis

6.      Other factors

7.      Inflammation (Neuro Inflammation)

8.      Trauma

9.      Loss of  cholinergic neurons

 

Aim of the Present Study:

Dimentia is a disorder which is caused due to loss of neurons in the brain or due to dehydration of acetylcholine in the nerve junction region or due to accumulation of NFT’s in the neurons.

 

Currently available drugs for treating Dimentia have been associated with number of side effects.

 

Treatment of dimentia involves acetylcholinesterace inhibitors, antioxidants such as Donepezil, Rivastigmin. The consumption of synthetic drugs leads to common cold, muscle cramps, diarrohea, vomiting, nausea, and some metabolic disorders.

 

Medicinal plants are used for various research purposes. It has been reported that traditional system has immune potential against various diseases. More than 13,000 plants have been studied for various pharmacological properties.

Herbal treatment for memory loss has no side effects and are local available. They are effective in reducing the oxidation property in animals.

 

The present study deals with the “Memory Enhancing Property of Santalum album in Mice”. The proper activity is monitored by the anti cholinesterase enzyme levels in β-Amyloid induced memory loss in mice.

 

Experimental methods:

Materials:

Selection of animals:

Wistar albino male mice of 40, weighing 80 -120 gm from center for animal house of kings institute, Gundy, Chennai. The animals were allow to acclimatize to the environment for 7 days and supplied with a standared pellet diet and water. The congenial temperature 30 O­­­­c ±­ 2 Oc and 12 hrs light and dark cycle were maintained.

 

Chemicals:

Amyloid – β – protein fragment 25 – 35 which was obtained from SIGMA – ACORICH, INC USA.

 

Experimental induction of memory loss in animal models:

β-amyloid is protein having a high molecular weight which causes the damage of the neurons in brain i.e., causes the memory loss.

Memory loss was induced to group I, II, III, IV, V, &VII animals by intra cranio ventricular route through a hamliton micro liter syringe and the dose is 10 micro liters per each animal.

 

Experimental design:

The mice were divided into 7 groups comprising of 3 animals in each group (for safety purpose minimum of 6 animals in each group we maintained, for statistical analysis only 3 animals in each group is taken into account).

 

Group I         : Positive control mice received 0.5 ml of Donapezil through oral route.

Group II        :   Negative control mice received 0.5 ml of the solvent through oral route

Group III      : Dimenita mice treated with Santalum album extract 0.2 ml is given orally.

Group IV       :  Dimenita mice treated with Santalum album extract 0.4 ml is given orally.

Group V        :  Dimenita mice treated with Santalum album extract 0.6 ml is given orally.

Group VI       :  0.5 ml of solvent without any induction with β amyloid.

Group VII     : In this group a combined dose of 0.5 ml of Donpezil  and 0.4 ml of medicine dose of Santalum album is given orally.

 

Experimental procedure:

Male albino mice of weighing around 15-20 gm which are one month old were taken for the study.

 

The mice were treated with graded dose of Santalum album extract. The dose grading from 50mg/Kg to 400mg/Kg were orally administered to the mice.

 

The standard Donepezil was also administered 0.5ml for the group I and VII i.e., dementia mice treated with Donepezil.

 

The treatment was carried out for 30 days and the acetylcholinesterace is calculated by taking the brain tissue. A normal group was also maintained with normal water groupVI.

 

 

At the end of the experimental period, the animals were sacrificed by   applying intra-peritoneal thiopentone (thiosol/ Na+). The brain was dissected out and cleaned with ice-cold saline, blotted dry, and immediately transferred to the ice chamber. Various oxidative stress and toxicity related biochemical parameters were estimated. The Animal Ethics Committee of the Institution approved the procedures.

 

RESULTS AND DISCUSSION:

Acetylcholinesterase levels:

Acetlycholinesterace is one of the important neuro transmitter which is helpful in the brain for storing the memory. During memory loss the Ach levels are drastically decreased which results from decresed in cognitive function.

 

Amyloid -β induced memory loss which causes damage in the neuronal junction and there is a decreased in the levels of Acetlycholinesterase levels in brain. Administration of Ethanolic extract of Santalum album to midly induced memory loss mice shows a increased levels in the Acetlcholinesterase.

 

Glutathione levels:

In the amyloid-β induced memory loss mice contains a high amount of the Glutathione levels. But after administration of the ehanolic extract of Santalum album for a period of 30 days. There is an change in decreased levels of GSH.

 

Excess release of Glutathione may cause the excitotoxity due to high intra cellular concentration of calcium, which causes neuronal dysfunction and death.

 

Antioxidant levels:

The brain derives nearly all the energy from mitochondrial oxidative phosphorylation, which generates ATP at same time as reducing molecular oxygen to water.  Under certain conditions reactive oxygen species are produced as side–products of this process.

 

These Reactive Oxygen species (ROS) attack many molecules such as membrane lipids and DNA.  These ROS accumulate and neurons become more susceptible to exocitotoxic damage. The extract of Santalum album has decreased the formation of reactive oxygen species. Because the Santalum album is having the capacity of anti oxidant activity.

 

CONCLUSION:

The plant Santalum album is known as Chandanam in Tamil. The whole property of the plant is having the medicinal active constituents.

 

The presence of various medicinally active chemicals such as Carbohydrates Triterpenoids, Volatile oils.

 

The biological activity of aqueous extract was effective for increasing the memory enhancing property. The plant could be subjected to further studies, which may lead to possibility of isolating the active principle from the plant.

 

The above results due to the presence of biologically active compounds along the trace elements of Santalum album extract exhibits the memory enhancing in the amyloid-β induced mice.

 

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Received on 30.10.2009

Accepted on 10.12.2009     

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Research J. Pharmacology and Pharmacodynamics 2(1): Jan. –Feb. 2010: 94-96